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研究業績（太田 智絵）

原著論文

2023年

  1. Kumatia EK, Ayertey F, Ohta T, Uto T, Tung NH.
    Iridoids from Morinda lucida, (Benth.) Rubiaceae, produced analgesic and anti-inflammatory activities via agonism at the kappa and delta opioid receptors, inhibition of COX-2 besides elevation of CAT and SOD activities.
    Journal of Ethnopharmacology, 309:116355. 2023.

2022年

  1. Fujii S, Ohta T, Ehama R, Irikida M, Nomura S, Shoyama Y, Uto T.
    Development of an indirect competitive enzyme-linked immunosorbent assay for formononetin and its application in a cell-based assay using MC3T3-E1 cells.
    Food Chemistry, In press. 2022.
  2. Ohta T, Inoha M, Kawahara C, Toshimitsu S, Shoyama Y, Uto T.
    Angiotensin I-converting enzyme-inhibitory activity and phytochemical profile of constituents of the leaves of Rehmannia glutinosa forma hueichingensis.
    Chemical and Pharmaceutical Bulletin, In press. 2022.
  3. Uto T, Ohta T, Nakayama E, Nakagawa M, Hatada M, Shoyama Y.
    Bioassay-guided fractionation of clove buds extract identifies eugenol as potent melanogenic inducer in melanoma cells.
    Journal of Oleo Science, 71(9): 1403-1412.
  4. Ohta T, Uto T, Shoyama Y, Sakyiamah MM, Appiah AA, Tanaka T.
    In vitro fertilization using sperm activated by ML-2-3 isolated from Morinda lucida Bentham leaves.
    Reproductive Medicine and Biology, 21(1):e12455. doi: 10.1002/rmb2.12455. 2022.
  5. Uto T, Ohta T, Katayama K, Shoyama Y.
    Silibinin promotes melanogenesis through the PKA and p38 MAPK signaling pathways in melanoma cells.
    Biomedical Research, 43(2):31-39. doi: 10.2220/biomedres.43.31. 2022.
  6. Uto T, Tung NH, Ohta T, Shoyama Y.
    (+)-Magnolin enhances melanogenesis in melanoma cells and three-dimensional human skin equivalent; Involvement of PKA- and p38 MAPK-signaling pathways.
    Planta Medica, 88(13):1199-1208. 2022.

2021年

  1. Ohta T, Uto T, Tanaka H.
    Effective methods for increasing coumestrol in soybean sprouts.
    PLoS One, 16(11):e0260147. doi: 10.1371/journal.pone.0260147. 2021.
  2. Okubo S, Ohta T, Shoyama Y, Uto T.
    Steroidal saponins isolated from the rhizome of Dioscorea tokoro inhibit cell growth and autophagy in hepatocellular carcinoma cells
    Life, 11(8):749. 2021.
  3. Okubo S, Ohta T, Fujita H, Shoyama Y, Uto T.
    Costunolide and dehydrocostuslactone from Saussurea lappa root inhibit autophagy in hepatocellular carcinoma.
    Journal of Natural Medicines, 75(1):240-245. 2021.

2020年

  1. Matsumoto T, Imahori D, Saito Y, Zhang W, Ohta T, Yoshida T, Nakayama Y, Ashihara E, Watanabe T.
    Cytotoxic activities of sesquiterpenoids from the aerial parts of Petasites japonicus against cancer stem cells.
    Journal of Natural Medicines, 74(4):689-701.2020.
  2. Aoki Y, Tsujimura A, Kaseda K, Okabe M, Tokuhiro K, Ohta T, O'Bryan MK, Okuda H, Kitamura K, Ogawa Y, Fujiki T, Wada M, Horie S, Nishimune Y, Tanaka H.
    Haprin-deficient spermatozoa are incapable of in vitro fertilization.
    Molecular Reproduction and Development, 87(5):534-541. 2020.
  3. Okubo S, Ohta T, Shoyama Y, Uto T.
    Arctigenin suppresses cell proliferation via autophagy inhibition in hepatocellular carcinoma cells.
    Journal of Natural Medicines, 74(3):525-532. 2020.
  4. Matsumoto T, Imahori D, Achiwa K, Saito Y, Ohta T, Yoshida T, Kojima N, Yamashita M, Nakayama Y, Watanabe T.
    Chemical structures and cytotoxic activities of the constituents isolated from Hibiscus tiliaceus.
    Fitoterapia, 142:104524. 2020.
  5. Tung NH, Ngan DT, Ohta T, Uto T, Watanabe H, Shoyama Y.
    Phytochemical profile of the aerial parts of Rehmannia glutinosa Liboschitz var. purpurea Makino.
    Pharmacognosy Magazine, 16(67):128-131. 2020.

2019年

  1. Kuchta K, Tung NH, Ohta T, Raekiansyah M, Grötzinger K, Rausch H, Shoyama Y, Rauwald HW, Morita K.
    The old pharmaceutical oleoresin labdanum of Cistus creticus L. exerts pronounced in vitro anti-dengue virus activity.
    Journal of Ethnopharmacology, 2019. In press.
  2. Uto T, Ohta T, Yamashita A, Fujii S, Shoyama Y.
    Liquiritin and liquiritigenin induce melanogenesis via enhancement of p38 and PKA signaling pathways.
    Medicines, 6(2):68. 2019.
  3. Okubo S, Komori H, Kuwahara A, Ohta T, Shoyama Y, Uto T.
    Screening of crude drugs used in Japanese Kampo formulas for autophagy-mediated cell survival of the human hepatocellular carcinoma cell line.
    Medicines, 6(2):63. 2019.
  4. Matsumoto T, Kitagawa T, Ohta T, Yoshida T, Imahori D, Teo S, Ahmad HSB, Watanabe T.
    Structures of triterpenoids from the leaves of Lansium domesticum
    Journal of Natural Medicines, 73(4):727-734. 2019.
  5. Fujimoto K, Ohta T, Yamaguchi H, Tung NH, Fujii G, Mutoh M, Uto T, Shoyama Y.
    Suppression of polyps formation by saffron extract in Adenomatous polyposis coliMin/+ Mice.
    Pharmacognosy Research, 11(1):98-101. 2019.
  6. Ohta T, Tilkanont T, Ayertey F, Nakagawa M, Tung NH, Bolah P, Blagogee H, Appiah AA, Ocloo A, Ohashi M, Tanoue K, Yamaguchi Y, Ohta N, Yamaoka S, Iwanaga S, Uto T, Shoyama Y.
    Establishment of a quantitative and qualitative analysis and isolation method for tetracyclic iridoids from Morinda lucida Bentham leaves.
    Journal of Pharmaceutical and Biomedical Analysis, 164:475-480. 2019.

2018年

  1. Azerigyik FA, Amoa-Bosompem M, Tetteh T, Ayertey F, Antwi AN, Owusu KB, Dadzie KK, Djameh GI, Tetteh-Tsifoanya M, Iwanaga S, Appiah AA, Ohta T, Uto T, Shoyama Y, Ohta N, Gwira TM, Ohashi M
    In vitro mechanistic assays of tetracyclic iridoid compounds isolated from Morinda lucida Benth in Leishmania species.
    European Journal of Medical Plants, 25(4). 1-14. 2018.
  2. Uto T, Tung NH, Ohta T, Juengsanguanpornsuk W, Hung LQ, Hai NT, Long DD, Thuong PT, Shinya O, Hirata S, Shoyama Y.
    Antiproliferative activity and apoptosis induction by trijuganone C isolated from the root of Salvia miltiorrhiza Bunge (Danshen).
    Phytotherapy Research, 32(4):657-666. 2018.

2017年

  1. Ohta T, Nakamura S, Nakashima S, Shimakawa H, Emi Y, Matsumoto T, Ogawa K, Fukaya M, Oda Y, Matsuda H.
    Stimulators of acylated ghrelin secretion from Moringa oleifera leaves.
    Photochemistry letters, 2:1-5. 2017.
  2. Ohta T, Nakamura S, Matsumoto T, Nakashima S, Ogawa K, Matsumoto T, Fukaya M, Yoshikawa M, Matsuda H.
    Chemical Structure of an Acylated Oleanane-type Triterpene Oligoglycoside and Anti-inflammatory Constituents from the Flower Buds of Camellia sinensis.
    Natural Product Communications, 12(8):1193-1196. 2017.
  3. Matsumoto T, Nakamura S, Nakashima S, Ohta T, Ogawa K, Fukaya M, Tsukioka J, Hasei T, Watanabe T, Matsuda H.
    Neolignan and megastigmane glucosides from the aerial parts of Isodon japonicus with cell protective effects on BaP-induced cytotoxicity.
    Photochemistry, 131:101-108. 2017.
  4. Tung NH, Nakajima K, Uto T, Hai NT, Long DD, Ohta T, Oiso S, Kariyazono H, Shoyama Y.
    Bioactive triterpenes from the root of Salvia miltiorrhiza Bunge.
    Phytotherapy Research, 31(9):1457-1460. 2017.

2016年

  1. Ohta T, Nakamura S, Nakashima S, Oda Y, Matsumoto T, Fukaya M, Yano M, Yoshikawa M, Matsuda H.
    Chemical structures of constituents from the whole plant of Bacopa monniera.
    Journal of Natural Medicine, 70(3):404−411. 2016.
  2. Nakashima S, Ohta T, Nakamura S, Oda Y, Koumoto M, Kashiwazaki E, Kado M, Shimada A, Akita R, Matsuda H.
    Caffeic Acid Derivatives from Bacopa monniera Plants as Inhibitors of Pancreatic Lipase Activity and their Structural Requirements.
    Natural Product Communications, 11(12):1855−1858. 2016.
  3. Matsumoto T, Nakamura S, Nakashima S, Ohta T, Yano M, Tsujihata J, Tsukioka J, Ogawa K, Fukaya M, Yoshikawa M, Matsuda H.
    γ-Lactam alkaloids from the flower buds of daylily.
    Journal of Natural Medicine, 70(3):376−383. 2016.

2015年

  1. Ohta T, Nakamura S, Nakashima S, Matsumoto T, Ogawa K, Fujimoto K, Fukaya M, Yoshikawa M, Matsuda H.
    Acylated oleanane-type triterpene oligoglycosides from the flower buds of Camellia sinensis var. assamica.
    Tetrahedron, 71(5):846−851. 2015.
  2. Matsumoto T, Nakamura S, Fujimoto K, Ohta T, Ogawa K, Yoshikawa M, Onishi E, Fukaya M, Matsuda H.
    Structures of diarylheptanoids with antiallergic activity from the rhizomes of Curcuma comosa.
    Journal of Natural Medicine, 69(1):142−147. 2015.
  3. Liu J, Nakamura S, Xu B, Matsumoto T, Ohta T, Fujimoto K, Ogawa K, Fukaya M, Miyake S, Yoshikawa M, Matsuda H.
    Chemical structures of constituents from the flowers of Osmanthus fragrans var. aurantiacus.
    Journal of Natural Medicine, 69(1):135−141. 2015.
  4. Ogawa K, Nakamura S, Sugimoto S, Tsukioka J, Hinomaru F, Nakashima S, Matsumoto T, Ohta T, Fujimoto K, Yoshikawa M, Matsuda H.
    Constituents of flowers of Paeoniaceae plants, Paeonia suffruticosa and Paeonia lactiflora.
    Phytochemistry Letters, 12:98−104. 2015.

2014年

  1. Matsumoto T, Nakamura S, Nakashima S, Fujimoto K, Yoshikawa M, Ohta T, Ogawa K, Matsuda H.
    Lignan Dicarboxylates and Terpenoids from the Flower Buds of Cananga odorata and Their Inhibitory Effects on Melanogenesis.
    Journal of Natural Products, 77(4):990−999. 2014.
  2. Matsumoto T, Nakamura S, Ohta T, Fujimoto K, Yoshikawa M, Ogawa K, Matsuda H.
    A Rare Glutamine Derivative from the Flower Buds of Daylily.
    Organic Letters, 16(11):3076−3078. 2014.
  3. Fujimoto K, Nakamura S, Matsumoto T, Ohta T, Yoshikawa M, Ogawa K, Kashiwazaki E, Matsuda H.
    Structures of acylated sucroses from the flower buds of Prunus mume.
    Journal of Natural Medicine, 68(3):481−487. (2014).
  4. Matsumoto T, Nakamura S, Fujimoto K, Ohta T, Ogawa K, Yoshikawa M, Matsuda H.
    Structure of constituents isolated from the flower buds of Cananga odorata and their inhibitory effects on aldose reductase.
    Journal of Natural Medicine, 68(4):709−716. 2014.

2013年

  1. Nakamura S, Nakashima S, Oda Y, Yokota N, Fujimoto K, Matsumoto T, Ohta T, Ogawa K, Maeda S, Nishida S, Matsuda H, Yoshikawa M.
    Alkaloids from Sri Lankan curry-leaf (Murraya koenigii) display melanogenesis inhibitory activity: Structures of karapinchamines A and B.
    Bioorganic & Medicinal Chemistry, 21(5):1043−1049. 2013.
  2. Matsumoto T, Nakamura S, Nakashima S, Yoshikawa M, Fujimoto K, Ohta T, Morita A, Yasui R, Kashiwazaki E, Matsuda H.
    Diarylheptanoids with inhibitory effects on melanogenesis from the rhizomes of Curcuma comosa in B16 melanoma cells.
    Bioorganic & Medicinal Chemistry Letters, 23(18):5178−5181. 2013.
  3. Nakamura S, Nakashima S, Tanabe G, Oda Y, Yokota N, Fujimoto K, Matsumoto T, Sakuma R, Ohta T, Ogawa K, Nishida S, Miki H, Matsuda H, Muraoka O, Yoshikawa M.
    Alkaloid constituents from flower buds and leaves of sacred lotus (Nelumbo nucifera, Nymphaeaceae) with melanogenesis inhibitory activity in B16 melanoma cells.
    Bioorganic & Medicinal Chemistry, 21(3):779–787. 2013.
  4. Fujimoto K, Nakamura S, Matsumoto T, Ohta T, Ogawa K, Tamura H, Matsuda H, Yoshikawa M.
    Medicinal Flowers. XXXVIII. Structure of Acylated Scroses and Inhibitory Effects of Constituents on Aldose Reducatase from the Flower Buds of Prunus mume.
    Chemical and Pharmaceutical Bulletin,61(4):445–451. 2013.
  5. Nakamura S, Fujimoto K, Matsumoto T, Nakashima S, Ohta T, Ogawa K, Matsuda H, Yoshikawa M.
    Acylated sucroses and acylated quinic acids analogs from the flower buds of Prunus mume and their inhibitory effect on melanogenesis.
    Phytochemistry, 92:128–136. 2013.
  6. Nakamura S, Fujimoto K, Matsumoto T, Ohta T, Ogawa K, Tamura H, Matsuda H, Yoshikawa M.
    Structures of acylated sucroses and an acylated flavonol glycoside and inhibitory effects of constituents on aldose reductase from the flower buds of Prunus mume.
    Journal of Natural Medicine, 67(4):799–806. 2013.

2012年

  1. Fujimoto K, Nakamura S, Nakashima S, Matsumoto T, Uno K, Ohta T, Miura T, Matsuda H, Yoshikawa M.
    Medicinal Flowers. XXXV. Nor-Oleanane-Type and Acylated Oleanane-Type Triterpene Saponins from the Flower Buds of Chinese Camellia japonica and Their Inhibitory Effects on Melanogenesis.
    Chemical and Pharmaceutical Bulletin,60(9):1188–1194. 2012.
  2. Nakamura S, Moriura T, Park S, Fujimoto K, Matsumoto T, Ohta T, Matsuda H, Yoshikawa M.
    Melanogenesis Inhibitory and Fibroblast Proliferation Accelerating Effects of Noroleanane- and Oleanane-Type Triterpene Oligoglycosides from the Flower Buds of Camellia japonica.
    Journal of Natural Products, 75(8):1425−1430. 2012.

総説

  1. Soeda S, Ohta T, Uto T, Shoyama Y.
    The effect of crocin on neuroprotective activity in vitro: a narrative review.
    Longhua Chinese Medicine, doi: org/10.21037/lcm-22-4. 2022.
  2. Sugiura M, Abe K, Saito H, Ohta T, Uto T, Shoyama Y.
    The effect of crocin on neuroprotective activity in vitro: a narrative review.
    Longhua Chinese Medicine, doi: 10.21037/lcm-22-5. 2022.
  3. Fujii S, Morita Y, Ohta T, Uto T, Shoyama Y.
    Saffron (Crocus sativus L.) as a valuable spice and food product: A narrative review.
    Longhua Chinese Medicine, doi: 10.21037/lcm-22-1. 2022.
  4. Uto T, Ohta T, Fujii S, Shoyama Y.
    Immunological separation of bioactive natural compounds from crude drug extract and its application for cell-based studies
    Antibodies (Basel), 10(4):48. doi: 10.3390/antib10040048. 2021.
  5. Uto T, Fujii S, Sakamoto S, Ohta T, Shoyama Y.
    Applications of monoclonal antibodies against natural compounds for functional analysis of crude drugs
    Current Pharmacology Reports, 6(4):192-201.2020.
  6. Uto T, Tung NH, Nakajima K, Ohta T, Oiso S, Kariyazono H, Shoyama Y.
    Bioactivities of Eriobotrya japonica (Thunb.) Lindl. leaf and its triterpenes.
    Journal of Pharmacognosy & Natural Products, 3:134. doi: 10.4172/2472-0992.1000134. 2017.

書籍

  1. Wang CZ, Anderson S, Ohta T, Uto T, Lee J, Tanaka H, Tung NH, Yuan CS.
    Chapter 2 "Analytical methodology of ginsenosides: Their health benefits, anticancer and antidementia activities: A review ".
    “Advances in Health and Disease. Volume 63”
    ISBN: 979-8-88697-544-4, Nova Science Publishers, 2023.01.12

その他の出版物

  1. Uto T, Tung NH, Ohta T, Rinta J, Lee IJ, Shoyama Y.
    Bioassay-guided fractionation and identification of active anti-inflammatory constituents from flower extract of Jasminum sambac.
    長崎国際大学論叢, 23：111-119, 2023.
  2. 太田智絵
    ウコンから血流を良くする新規成分を発見！？
    ファルマシア，55(11):1074, 2019.

特許

  1. メラニン産生促進剤およびその製造方法
    橋本雅和，小島弘之，宇都拓洋，太田智絵
    一丸ファルコス株式会社，長崎国際大学
    2023年2月21日
    出願番号：特願2023-025264
  2. もやしクメストロール含有率増加方法出
    田中宏光，太田智絵，宇都拓洋
    長崎国際大学
    2022年４月11日
    出願番号：特願2021-39850
  3. メラニン合成促進組成物
    田中宏光，太田智絵，宇都拓洋
    長崎国際大学
    2017年8月1日
    出願番号：特願2017-149066

学内の表彰

  1. 2019年5月：ベストティーチャー賞 ベストプラクティス部門（地域貢献活動等、共同受賞）
  2. 2021年4月：学長特別表彰
  3. 2022年4月：学長特別表彰
  4. 2022年6月：ベストティーチャー賞 ベストプラクティス部門（研究活動等）

研究資金の採択状況

  1. 2018年度～2020年度：科学研究費 若手研究（代表）
  2. 2021年度～2024年度：科学研究費 若手研究（代表）

学外活動

«所属学会名»

日本生薬学会、日本薬学会

«学術論文等の審査»

年 外国語雑誌査読論文数 日本語雑誌査読論文数
2020年 4 －
2019年 9 －
2018年 9 －
2017年 2 －

その他

  1. JST女子中高校生の理系進路選択支援プログラム「継続･育成型 STEAM ガールズ in SAGA･SASEBO」
    【リケジョ×ワタシノ#】未来に輝く長崎国際大のリケジョ　出演
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