長崎国際大学 薬学部 薬品資源学研究室

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研究業績

※2010年以降のみ掲載しています。

原著論文

2019年

  1. Tung NH, Ngan DT, Ohta T, Uto T, Watanabe H, Shoyama Y.
    Phytochemical profile of the aerial parts of Rehmannia glutinosa Liboschitz var. purpurea Makino.
    Pharmacognosy Magazine, 2019. In press.
  2. Uto T, Ohta T, Yamashita A, Fujii S, Shoyama Y.
    Liquiritin and liquiritigenin induce melanogenesis via enhancement of p38 and PKA signaling pathways.
    Medicines, 2019. In press.
  3. Matsumoto T, Kitagawa T, Ohta T, Yoshida T, Imahori D, Teo S, Ahmad HSB, Watanabe T.
    Structures of triterpenoids from the leaves of Lansium domesticum
    Journal of Natural Medicines, 2019. In press.
  4. Okubo S, Komori H, Kuwahara A, Ohta T, Shoyama Y, Uto T. Screening of crude drugs used in Japanese Kampo formulas for autophagy-mediated cell survival of the human hepatocellular carcinoma cell line.
    Medicines, 2019. In press.
  5. Fujimoto K, Ohta T, Yamaguchi H, Tung NH, Fujii G, Mutoh M, Uto T, Shoyama Y.
    Suppression of polyps formation by saffron extract in Adenomatous polyposis coliMin/+ Mice.
    Pharmacognosy Research, 11(1):98-101. 2019.
  6. Ohta T, Tilkanont T, Ayertey F, Nakagawa M, Tung NH, Bolah P, Blagogee H, Appiah AA, Ocloo A, Ohashi M, Tanoue K, Yamaguchi Y, Ohta N, Yamaoka S, Iwanaga S, Uto T, Shoyama Y.
    Establishment of a quantitative and qualitative analysis and isolation method for tetracyclic iridoids from Morinda lucida Bentham leaves.
    Journal of Pharmaceutical and Biomedical Analysis, 164:475-480. 2019.

2018年

  1. Nishide A, Shoyama U, Yamamoto T, Fujita T, Ohnuki K, Watanabe T, Nagaregawa Y, Shimizu S, Ohnuki K.
    Sleep enhancement by saffron extract in randomized control trial.
    Japanese Pharmacology & Therapeitics, 46. 1407-1415. 2018.
  2. Aoki Y, Tsujimura A, Nagashima Y, Hiramatsu I, Uesaka Y, Nozaki T, Ogishima T, Shirai T, Shoyama Y, Tanaka H, Horie S.
    Effect of Lepidium meyenii on in vitro fertilization via improvement in acrosome reaction and motility of mouse and human sperm.
    Reproductive Medicine and Biology, 18. 57-64(1). 2018.
  3. Azerigyik FA, Amoa-Bosompem M, Tetteh T, Ayertey F, Antwi AN, Owusu KB, Dadzie KK, Djameh GI, Tetteh-Tsifoanya M, Iwanaga S, Appiah AA, Ohta T, Uto T, Shoyama Y, Ohta N, Gwira TM, Ohashi M.
    In vitro mechanistic assays of tetracyclic iridoid compounds isolated from Morinda lucida Benth in Leishmania species.
    European Journal of Medical Plants, 25(4). 1-14. 2018.
  4. Ohashi M, Amoa-Bosompem M, Kwofie KD, Agyapong J, Adegle R, Sakyiamah MM, Ayertey F, Owusu KB, Tuffour I, Atchoglo P, Tung NH, Uto T, Aboagye F, Appiah AA, Appiah-Opong R, Nyarko AK, Anyan WK, Ayi I, Boakye DA, Koram KA, Edoh D, Yamaoka S, Shoyama Y,Ohta N.
    In vitro anti-protozoan activity and mechanisms of action of selected Ghanaian medicinal plants against Trypanosoma, Leishmania and Plasmodium parasites.
    Phytotherapy Research, 32(8):1617-1630. 2018.
  5. Uto T, Tung NH, Ohta T, Juengsanguanpornsuk W, Hung LQ, Hai NT, Long DD, Thuong PT, Okubo S, Hirata S, Shoyama Y. Antiproliferative activity and apoptosis induction by trijuganone C isolated from the root of Salvia miltiorrhiza Bunge (Danshen).
    Phytotherapy Research, 32(4):657-666. 2018.
  6. Cui Q, Tanaka H, Shoyama Y, Ye HT, Li F, Tian EW, Wu YS, Chao Z.
    Development of a competitive time-resolved fluoroimmunoassay for paclitaxel.
    Phytochemical Analysis, 29(3):284-289. 2018.
  7. Fujii S, Uto T, Nomura S, Shoyama Y.
    Preparation of anti-glycyrrhetinic acid monoclonal antibody for application in an indirect competitive enzyme-linked immunosorbent assay.
    Analytical Letters, 51(8): 1147-1162. 2018.

2017年

  1. Tanaka H, Haraguchi T, Wada M, Shoyama Y.
    Localization of herbal medicine substances in sperm that increase fertilization rate during mouse IVF.
    International Journal of Reproduction, Fertility & Sexual Health, 4(5):113-115. 2017.
  2. Antwi AN, Owusu KBA, Amoa-Bosompem M, Williams NB, Ayertey F, Akyeh L, Agyapong J, Tetteh T, Djameh GI, Botchie S, Azerigyik F, Ablordey A, Tung NH, Uto T, Appiah AA, Iwanaga S, Shoyama Y, Ohta N, Egyir B, Ohashi M.
    Anti-microbial activities of selected Ghanaian medicinal plants and four structurally similar anti-protozoan compounds against susceptible and multi-drug resistant bacteria.
    European Journal of Medical Plants, 20(2):1-14. 2017.
  3. Okubo S, Uto T, Goto A, Tanaka H, Nishioku T, Yamada K, Shoyama Y.
    Berberine induces apoptotic cell death via activation of caspase-3 and -8 in HL-60 human leukemia cells: Nuclear localization and structure-activity relationships.
    The American Journal of Chinese Medicine,45(7):1497-1511. 2017.
  4. Tung NH, Nakajima K, Uto T, Hai NT, Long DD, Ohta T, Oiso S, Kariyazono H, Shoyama Y.
    Bioactive triterpenes from the root of Salvia miltiorrhiza Bunge.
    Phytotherapy Research,31(9):1457-1460. 2017.
  5. Tung NH, Uto T, Hai NT, Li G, Shoyama Y.
    Quassinoids from the root of Eurycoma longifolia and their antiproliferative activity on human cancer cell lines.
    Pharmacognosy Magazine,13(51):459-462. 2017.
  6. Fujii S, Morinaga O, Uto T, Nomura S, Shoyama Y.
    Simultaneous determination of glycyrrhizin and liquiritin in licorice roots and Kampo medicines by combination enzyme-linked immunosorbent assay using anti-glycyrrhizin and anti-liquiritin monoclonal antibodies.
    Journal of Immunoassay and Immunochemistry, 38(3):285-298. 2017.

2016年

  1. Nakajima K, Oiso S, Uto T, Morinaga O, Shoyama Y, Kariyazono H.
    Triterpenes suppress octanoylated ghrelin production in ghrelin-expressing human gastric carcinoma cells.
    Biomedical Research, 37(6):343-349. 2016.
  2. Amoa-Bosompem M, Ohashi M, Mosore MT, Agyapong J, Tung NH, Kwofie KD, Ayertey F, Owusu KB, Tuffour I, Atchoglo P, Djameh GI, Azerigyik FA, Botchie SK, Anyan WK, Appiah-Opong R, Uto T, Morinaga O, Appiah AA, Ayi I, Shoyama Y, Boakye DA, Ohta N.
    In vitro anti-Leishmania activity of tetracyclic iridoids from Morinda lucida, benth.
    Tropical Medicine and Health, 44:25. doi: 10.1186/s41182-016-0026-5. 2016.
  3. Tung NH, Uto T, Isoda S, Shoyama Y.
    Investigation of ginsenoside Rb1 from Acanthopanax koreanum by Eastern blotting and ELISA analyses.
    Pharmaceutical Analytical Chemistry, 2:116. doi:10.4172/2471-2698.1000116. 2016.
  4. Uto T, Tung NH, Thongjankaew P, Lhieochaiphant S, Shoyama Y.
    Kayeassamin A isolated from the flower of Mammea siamensis triggers apoptosis by activating caspase-3/-8 in HL-60 human leukemia cells.
    Pharmacognosy Research, 8(4):244-248. 2016
  5. Kwofie KD, Tung NH, Suzuki-Ohashi M, Amoa-Bosompem M, Adegle R, Sakyiamah MM, Ayertey F, Owusu KB, Tuffour I, Atchoglo P, Frempong KK, Anyan WK, Uto T, Morinaga O, Yamashita T, Aboagye F, Appiah AA, Appiah-Opong R, Nyarko AK, Yamaguchi Y, Edoh D, Koram KA, Yamaoka S, Boakye DA, Ohta N, Shoyama Y, Ayi I.
    Antitrypanosomal activities and mechanisms of action of novel tetracyclic iridoids from Morinda lucida Benth.
    Antimicrobial Agents and Chemotherapy, 60(6):3283-3290. 2016.
  6. Wang D, Li XW, Wang X, Tan HR, Jia Y, Yang L, Li XM, Shang MY, Xu F, Yang XX, Shoyama Y, Cai SQ.
    Alpha-actinin-4 is a possible target protein for aristolochic acid I in human kidney cells in vitro.
    The American Journal of Chinese Medicine, 44(2):291-304. 2016.
  7. Chao Z, Cui Q, Tian E, Zeng W, Cai X, Li X, Tanaka H, Shoyama Y, Wu Y.
    Ultrasensitive time-resolved fluoroimmunoassay for saikosaponin a in Chaihu (Bupleuri Radix).
    PLoS One, 11(3):e0151032. 2016.
  8. Fujii S, Morinaga O, Uto T, Nomura S, Shoyama Y.
    Development of double eastern blotting for major licorice components, glycyrrhizin and liquiritin for chemical quality control of licorice using anti-glycyrrhizin and anti-liquiritin monoclonal antibodies.
    Journal of Agricultural and Food Chemistry, 64(5):1087-1089. 2016.

2015年

  1. Karasawa S, Yoza K, Tung NH, Uto T, Morinaga O, Suzuki M, Kwofie K.D., Amoa-Bosompem M, Boakye DA, Ayi I, Adegle R, Sakyiamah M, Ayertey F, Aboagye F, Appiah AA, Owusu KB, Tuffour I, Atchoglo P, Frempong KK, Anyan WK, Appiah-Opong R, Nyarko AK, Yamashita T, Yamaguchi Y, Edoh D, Koram K, Yamaoka S, Ohta N, Shoyama Y.
    Determination of the absolute configuration of the novel anti-trypanosomal iridoid molucidin isolated from Morinda lucida by X-ray analysis.
    Tetrahedron Letters, 56(52):7158-7160. 2015.
  2. Uto T, Tung NH, Taniyama R, Miyanowaki T, Morinaga O, Shoyama Y.
    Anti-inflammatory activity of constituents isolated from aerial part of Angelica acutiloba Kitagawa.
    Phytotherapy Research, 29(12): 1956-1963. 2015.
  3. Tung NH, Shoyama Y, Wada M, Tanaka H.
    Two activators of in vitro fertilization in mice from licorice.
    Biochemical and Biophysical Research Communications, 467(2):447-450. 2015.
  4. Uto T, Tung NH, Appiah-Opong R, Aning A, Morinaga O, Edoh D, Nyarko AK, Shoyama Y.
    Antiproliferative and pro-apoptotic activity of diarylheptanoids isolated from the bark of Alnus japonica in human leukemia cell lines.
    American Journal of Chinese Medicine, 43(4):757-767. 2015.
  5. Tung NH, Uto T, Morinaga O, Shoyama Y.
    Chemical constituents from the aerial parts of Bupleurum falcatum L. and biological evidences.
    Natural Product Sciences, 21(2), 71-75. 2015.
  6. Suzuki M, Tung NH, Kwofie KD, Adegle R, Amoa-Bosompem M, Sakyiamah M, Ayertey F, Owusu KB, Tuffour I, Atchoglo P, Frempong KK, Anyan WK, Uto T, Morinaga O, Yamashita T, Aboagye F, Appiah AA, Appiah-Opong R, Nyarko AK, Yamaoka S, Yamaguchi Y, Edoh D, Koram K, Ohta N, Boakye DA, Ayi I, Shoyama Y.
    New anti-trypanosomal active tetracyclic iridoid isolated from Morinda lucida Benth.
    Bioorganic & Medicinal Chemistry Letters, 25(15):3030-3033. 2015
  7. Hori T, Barnor J, Huu TN, Morinaga O, Hamano A, Ndzinu J, Frimpong A, Minta-Asare K, Amoa-Bosompem M, Brandful J, Odoom J, Bonney J, Tuffour I, Owusu BA, Ofosuhene M, Atchoglo P, Sakyiamah M, Adegle R, Appiah-Opong R, Ampofo W, Koram K, Nyarko A, Okine L, Edoh D, Appiah A, Uto T, Yoshinaka Y, Uota S, Shoyama Y, Yamaoka S.
    Procyanidin trimer C1 derived from Theobroma cacao reactivates latent human immunodeficiency virus type 1 provirus.
    Biochemical and Biophysical Research Communications, 459(2):288-293. 2015.
  8. Oiso S, Morinaga O, Goroku T, Uto T, Shoyama Y, Kariyazono H.
    Generation of an anti-dabigatran monoclonal antibody and its use in a highly sensitive and specific enzyme-linked immunosorbent assay for serum dabigatran.
    Therapeutic Drug Monitoring, 37(5):594-599. 2015.
  9. Cui Y, Wang YJ, Zhao DY, Shoyama Y, Li G, Liu C.
    Effects of Crocin on Bcl-2,Bax and Caspase-3 Expression of PC12 Cells Injured by H2O2.
    Natural Product Research and Development, 3:411-415, 2015. 
  10. Sakamoto S, Uto T, Shoyama Y.
    Effect of glycyrrhetinic acid on lipid raft model at the air/water interface.
    Biochimica et Biophysica Acta (BBA), 1848(2):434-443. 2015.
  11. Tanaka T, Mori CS, Yuan S, Soed S, Tung NH, Shoyama Y.
    The function of saffron and its constituent in gastroenterological tissues
    Global Journal of Gastroenterology & Hepatology, 3:31-38, 2015.

2014年

  1. Li XW, Yokota S, Wang D, Wang X, Shoyama Y, Cai SQ. Localization of aristolochic acid in mouse kidney tissues by immunohistochemistry using an anti-AA-I and AA-II monoclonal antibody.
    American Journal of Chinese Medicine, 42(6):1453-1469. 2014.
  2. Tung NH, Suzuki M, Uto T, Morinaga O, Kwofie KD, Ammah N, Koram KA, Aboagye F, Edoh D, Yamashita T, Yamaguchi Y, Setsu T, Yamaoka S, Ohta N, Shoyama Y.
    Anti-trypanosomal activity of diarylheptanoids isolated from the bark of Alnus japonica.
    American Journal of Chinese Medicine, 2014;42(5):1245-1260. 2014.
  3. Tung NH, Sun K, Fan JY, Shoyama Y, Han JY.
    Oregonin from the Bark of Alnus japonica restrained ischemia-reperfusion-induced mesentery oxidative stress by inhibiting NADPH oxidase activation.
    Microcirculation, 21(8):688-695. 2014.
  4. Fujii S, Tuvshintogtokh I, Mandakh B, Munkhjargal B, Uto T, Morinaga O, Shoyama Y.
    Screening of Glycyrrhiza uralensis Fisch. ex DC. containing high concentrations of glycyrrhizin by Eastern blotting and enzyme-linked immunosorbent assay using anti-glycyrrhizin monoclonal antibody for selective breeding of licorice.
    Journal of Natural Medicines, 68(4):717-722. 2014.
  5. Fujii S, Morinaga O, Uto T, Nomura S, Shoyama Y.
    Development of a monoclonal antibody-based immunochemical assay for liquiritin and its application to the quality control of licorice products.
    Journal of Agricultural and Food Chemistry, 62(15):3377-3383. 2014.
  6. Limsuwanchote S, Wungsintaweekul J, Yusakul G, Han JY, Sasaki-Tabata K, Tanaka H, Shoyama Y, Morimoto S.
    Preparation of a monoclonal antibody against notoginsenoside R1, a distinctive saponin from Panax notoginseng, and its application to indirect competitive ELISA.
    Planta Medica, 80(4):337-342. 2014.
  7. Tung NH, Shoyama Y, Wada M, Tanaka H.
    Improved in vitro fertilization ability of mouse sperm caused by the addition of licorice extract to the preincubation medium.
    The Open Reproductive Science Journal, 6:1-7, 2014.

2013年

  1. Tung NH, Du GJ, Yuan CS, Shoyama Y, Wang CZ.
    Isolation and chemopreventive evaluation of novel naphthoquinone compounds from Alkanna tinctoria.
    Anticancer Drugs, 24(10):1058-1068. 2013.
  2. Li XW, Morinaga O, Tian M, Uto T, Yu J, Shang MY, Wang X, Cai SQ, Shoyama Y.
    Development of an Eastern blotting technique for the visual detection of aristolochic acids in Aristolochia and Asarum species by using a monoclonal antibody against aristolochic acids I and II.
    Phytochemical Analysis,
    24(6):645-653. 2013.
  3. Zhang Z, Wang CZ, Wen XD, Shoyama Y, Yuan CS.
    Role of saffron and its constituents on cancer chemoprevention.
    Pharmaceutical Biology, 51(7):920-924. 2013.
  4. Shoyama Y, Yuan CS, Chen D, Wenger T.
    Antiaging active natural products.
    Evidence-Based Complementary and Alternative Medicine, 2013: Article ID 685675. 2013.
  5. Uto T, Sakamoto A, Tung NH, Fujiki T, Kishihara K, Oiso S, Kariyazono H, Morinaga O, Shoyama Y.
    Anti-proliferative activities and apoptosis induction by triterpenes derived from Eriobotrya japonica in human leukemia cell lines.
    International Journal of Molecular Sciences, 14(2): Article ID 4106-20. 2013.
  6. Sakamoto S, Nakahara H, Uto T, Shoyama Y, Shibata O.
    Investigation of interfacial behavior of glycyrrhizin with a lipid raft model via a Langmuir monolayer study.
    Biochimica et Biophysica Acta (BBA), 1828(4):1271-1283. 2013.
  7. Tung NH, Shoyama Y.
    New minor glycoside components from saffron.
    Journal of Natural Medicines, 67(3):672-676. 2013.
  8. Chao Z, Tan M, Paudel MK, Sakamoto S, Ma L, Sasaki-Tabata K, Tanaka H, Shoyama Y, Xuan L, Morimoto S.
    Development of an indirect competitive enzyme-linked immunosorbent assay (icELISA) using highly specific monoclonal antibody against paclitaxel.
    Journal of Natural Medicines, 67(3):512-518. 2013.
  9. Morinaga O, Lu Z, Lin L, Uto T, Sangmalee S, Putalun W, Tanaka H, Shoyama Y.
    Detection of paeoniflorin and albiflorin by immunostaining technique using anti-paeoniflorin monoclonal antibody.
    Phytochemical Analysis, 24(2):124-128. 2013.
  10. Huu Tung N, Du GJ, Wang CZ, Yuan CS, Shoyama Y.
    Naphthoquinone components from Alkanna tinctoria (L.) Tausch show significant antiproliferative effects on human colorectal cancer cells.
    Phytotherapy Research, 27(1):66-70. 2013.
  11. Uto T, Tung NH, Morinaga O, Shoyama Y.
    Interaction analysis of glycyrrhizin on licorice extract-induced apoptosis of human leukemia cells by knockout extract.
    Natural Products Chemistry & Research, 1(105): Article ID 1000105. 2013.
  12. Tung NH, Uto T, Sakamoto A, Hayashida Y, Hidaka Y, Morinaga O, Lhieochaiphant S, Shoyama Y.
    Antiproliferative and apoptotic effects of compounds from the flower of Mammea siamensis (Miq.) T. Anders. on human cancer cell lines.
    Bioorganic & Medicinal Chemistry Letters, 23(1):158-162. 2013.

2012年

  1. Kawabata K, Tung NH, Shoyama Y, Sugie S, Mori T, Tanaka T.
    Dietary crocin inhibits colitis and colitis-associated colorectal carcinogenesis in male ICR mice.
    Evidence-Based Complementary and Alternative Medicine, 2012: Article ID 820415. 2012.
  2. Tung NH, Shoyama Y.
    Eastern blotting analysis and isolation of two new dammarane-type saponins from American ginseng.
    Chemical & Pharmaceutical Bulletin, 2012;60(10):1329-1333. 2012.
  3. Shoyama Y, Tamada T, Kurihara K, Takeuchi A, Taura F, Arai S, Blaber M, Shoyama Y, Morimoto S, Kuroki R.
    Structure and function of ∆1-tetrahydrocannabinolic acid (THCA) synthase, the enzyme controlling the psychoactivity of Cannabis sativa.
    Journal of Molecular Biology, 423(1):96-105. 2012.
  4. Paudel MK, Takei A, Sakoda J, Juengwatanatrakul T, Sasaki-Tabata K, Putalun W, Shoyama Y, Tanaka H, Morimoto S.
    Preparation of a single-chain variable fragment and a recombinant antigen-binding fragment against the anti-malarial drugs, artemisinin and artesunate, and their application in an ELISA.
    Analytical Chemistry, 84(4):2002-2008. 2012.
  5. Uto T, Morinaga O, Tanaka H, Shoyama Y.
    Analysis of the synergistic effect of glycyrrhizin and other constituents in licorice extract on lipopolysaccharide-induced nitric oxide production using knock-out extract.
    Biochemical and Biophysical Research Communications, 417(1):473-478. 2012.
  6. Uto T, Qin GW, Morinaga O, Shoyama Y.
    17-Hydroxy-jolkinolide B, a diterpenoid from Euphorbia fischeriana, inhibits inflammatory mediators but activates heme oxygenase-1 expression in lipopolysaccharide-stimulated murine macrophages.
    International Immunopharmacology, 12(1):101-109. 2012.
  7. Masaki M, Aritake K, Tanaka H, Shoyama Y, Huang ZL, Urade Y.
    Crocin promotes non-rapid eye movement sleep in mice.
    Molecular Nutrition & Food Research, 56(2):304-308. 2012.
  8. Sakamoto S, Putalun W, Pongkitwitoon B, Juengwatanatrakul T, Shoyama Y, Tanaka H, Morimoto S. Modulation of plumbagin production in Plumbago zeylanica using a single-chain variable fragment antibody against plumbagin.
    Plant Cell Reports, 31(1):103-110. 2012.
  9. Tsukiyama M, Sugita T, Kikuchi H, Yasuda Y, Arashima M, Okumura H, Lhieochaiphant S, Shoyama Y.
    Bioactivities of Duabanga grandiflora for human skin cells.
    Traditional and Folk Herbal Medicine, 1: 53-66, 2-12, 2012.
  10. Du XM, Shoyama Y.
    Biological activities of Anoectochilus formosanus Hayat and its active component.
    Bioactive Phytochemicals, 1; 477-494, 2012.
  11. Morinaga O, Mukae R, Uto T, Pariyawongsakul Y, Putalun W, Tanaka H, Shoyama Y.
    Development of Eastern blotting technique for analysis of baicalin using anti-baicalin monoclonal antibody.
    Antibodies, 1(3): 284-293, 2012.

2011年

  1. Wongwicha W, Tanaka H, Shoyama Y, Putalun W.
    Methyl jasmonate elicitation enhances glycyrrhizin production in Glycyrrhiza inflata hairy roots cultures.
    Zeitschrift für Naturforschung C, 66(7-8):423-428. 2011.
  2. Paudel MK, Putalun W, Sritularak B, Morinaga O, Shoyama Y, Tanaka H, Morimoto S.
    Development of a combined technique using a rapid one-step immunochromatographic assay and indirect competitive ELISA for the rapid detection of baicalin.
    Analytica Chimica Acta, 701(2):189-193. 2011.
  3. Hirunuma M, Shoyama Y, Sasaki K, Sakamoto S, Taura F, Shoyama Y, Tanaka H, Morimoto S. Flavone-catalyzed apoptosis in Scutellaria baicalensis.
    Phytochemistry, 72(8):752-760. 2011.
  4. Yokota S, Onohara Y, Shoyama Y.
    Immunofluorescence and immunoelectron microscopic localization of medicinal substance, Rb1, in several plant parts of Panax ginseng.
    Current Drug Discovery Technologies, 8(1):51-59. 2011.
  5. Pongkitwitoon B, Sakamoto S, Morinaga O, Juengwatanatrakul T, Shoyama Y, Tanaka H, Morimoto S.
    Single-chain variable fragment antibody against ginsenoside Re as an effective tool for the determination of ginsenosides in various ginsengs.
    Journal of Natural Medicines, 65(1):24-30. 2011.
  6. Yokota S, Onohara Y, Uto T, Tanaka H, Morinaga O, Shoyama Y.
    Localization of ginsenoside-Rb1 in Panax ginseng revealed by immunofluorescence and immunoelectron microscopic techniques.
    Journal of Medicinal Plants Research, 5(14): 3176-3187, 2011.

2010年

  1. Uto T, Suangkaew N, Morinaga O, Kariyazono H, Oiso S, Shoyama Y.
    Eriobotryae folium extract suppresses LPS-induced iNOS and COX-2 expression by inhibition of NF-kB and MAPK activation in murine macrophages.
    American Journal of Chinese Medicine, 38(5):985-994. 2010.
  2. Tsukiyama M, Sugita T, Kikuchi H, Yasuda Y, Arashima M, Okumura H, Lhieochaiphant S, Shoyama Y.
    Effect of Duabanga grandiflora for human skin cells.
    American Journal of Chinese Medicine, 38(2):387-399. 2010.
  3. Morinaga O, Uto T, Yuan CS, Tanaka H, Shoyama Y.
    Evaluation of a new eastern blotting technique for the analysis of ginsenoside Re in American ginseng berry pulp extracts.
    Fitoterapia, 81(4):284-288. 2010.
  4. Wang CZ, Aung HH, Mehendale SR, Shoyama Y, Yuan CS. High performance liquid chromatographic analysis and anticancer potential of Oplopanax horridus: comparison of stem and berry extracts.
    Fitoterapia, 81(2):132-139. 2010.

総説

2019年

  1. 渡辺 和人,正山 征洋
    大麻成分ファイトカンナビノイドの変遷
    第一薬科大学研究年報, 25:1-20. 2019.

2018年

  1. Dai HF, Ohta T, Uto T, Shoyama Y.
    New development of artificial agarwood in Hainan in China.
    薬用植物研究, 40(1):1-10. 2018.
  2. Sakamoto S, Putalun W, Vimolmangkang S, Phoolcharoen W, Shoyama Y, Tanaka H, Morimoto S.
    Enzyme-linked immunosorbent assay for the quantitative/qualitative analysis of plant secondary metabolites.
    Journal of Natural Medicines, 72(1):32-42. 2018.

2017年

  1. Shoyama Y.
    Monoclonal antibody usage strategies for natural products in traditional chinese medicine.
    World Journal of Traditional Chinese Medicine, 3:18-27. 2017.
  2. 正山征洋、田中宏光
    精子を活性化する甘草
    薬用植物研究, 39(2):1-46. 2017.
  3. 正山征洋
    大麻の鑑識と最近の乱用薬物事情
    長崎国際大学論叢, 17:233-229. 2017.
  4. 正山征洋
    薬害をひきおこした薬草
    長崎国際大学論叢, 17:247-252. 2017.
  5. 藤井 俊輔, 宇都 拓洋, 正山 征洋
    天然化合物特異的モノクローナル抗体を用いた薬用植物の品質評価法
    アグリバイオ, 1(7):62-65. 2017.
  6. 藤井 俊輔, 宇都 拓洋, 正山 征洋
    甘草含有成分に対するモノクローナル抗体を用いた甘草の品質評価法の開発
    アグリバイオ, 1(4):72-75. 2017.
  7. Uto T, Tung NH, Nakajima K, Ohta T, Oiso S, Kariyazono H, Shoyama Y.
    Bioactivities of Eriobotrya japonica (Thunb.) Lindl. leaf and its triterpenes.
    Journal of Pharmacognosy & Natural Products, 3:134. doi: 10.4172/2472-0992.1000134. 2017.

2016年

  1. Fujii S, Tung NH, Uto T, Tanaka H, Li XW, Cai SQ, Putalum W, Shoyama Y.
    Quality control of natural products by fingerprinting of eastern blotting.
    Pharmaceutica Analytica Acta, 7:494. doi: 10.4172/2153-2435.1000494. 2016.
  2. Soeda S, Aritake K, Urade Y, Sato H, Shoyama Y.
    Neuroprotective activities of saffron and crocin.
    Advances in Neurobiology, 12:275-292. 2016.
  3. Tung NH, Wang CZ, Du GJ, Yuan CS, Uto T, Shoyama Y.
    Chemopreventive activity of naphthoquinones from Alkanna tinctoria (L.) Tausch in human colorectal cancer cells.
    Journal of Gastroenterology and Hepatology Research, 5(4):2115-2121.2016.
  4. Tung NH, Tanaka H, Tsujimura A, Miyagawa Y, Wada M, Fujii S, Uto T, Shoyama Y.
    In vitro fertilization with mouse sperm activated by components of licorice root extract.
    Natural Products Chemistry & Research, 4(3), doi:10.4172/2329-6836.1000217. 2016.
  5. 正山征洋
    特集「植物資源の機能性開発」に寄せて
    Foods & Food Ingredients Journal of Japan, 221(2):86-82. 2016.
  6. 正山征洋
    サフランの多機能性薬理活性
    Foods & Food Ingredients Journal of Japan, 221(2):117-124. 2016.
  7. 正山征洋
    東洋と西洋の紫色素
    長崎国際大学論叢,16:177-185. 2016.

2015年

  1. 宇都拓洋, Tung NH, 正山征洋
    生薬未利用部位の開発研究 柴胡・当帰
    薬用植物研究,37(2):38-48. 2015.
  2. Putalun W., Tanaka H., Wakana A., Uto T., Shoyama Y.
    Missile-type molecular breeding of medicinal plant using compact monoclonal antibody gene.
    EC Agriculture, 2(3), 358-365. 2015.

2014年

  1. Sakamoto S, Shoyama Y, Tanaka H, Morimoto S.
    Application of green fluorescent protein in immunoassays.
    Advances in Bioscience and Biotechnology, 5(6):557-563, 2014.
  2. 正山征洋
    薬用植物図説 ―ボタニカルアートから見た薬用植物―
    長崎国際大学論叢,14:215-245, 2014.

2013年

  1. 正山征洋
    漢方薬資源のなかの甘草の枯渇克服を目指して -漢方薬の危機管理-
    長崎国際大学論叢,13:133-143, 2013.

2012年

  1. Huu Tung N, Uto T, Morinaga O, Kim YH, Shoyama Y.
    Pharmacological effects of ginseng on liver functions and diseases: a minireview.
    Evidence-Based Complementary and Alternative Medicine, 2012: Article ID 173297. 2012.
  2. Uto T, Hou DX, Morinaga O, Shoyama Y.
    Molecular mechanisms underlying anti-inflammatory actions of 6-(methylsulfinyl)hexyl isothiocyanate derived from wasabi (Wasabia japonica).
    Advances in Pharmacological Sciences, 2012: Article ID 614046. 2012.
  3. Tanaka H, Morinaga O, Uto T, Fuji S, Aboagye FA, Tung NH, Li XW, Putalun W, Shoyama Y.
    Application of monoclonal antibodies against bioactive natural products: Eastern blotting and preparation of knockout extract.
    International Journal of Analytical Chemistry, 2012: Article ID 260425. 2012.
  4. Kwon ST, Uto T, Morinaga O, Tung NH, Tanaka H, Yuan CS, Shoyama Y.
    A new strategy of immunostaining for identification of ginsenosides.
    International Journal of Biomedical and Pharmaceutical Sciences, 6(Special issue 1): 101-105, 2012.
  5. Tanaka H, Putalun W, Shoyama Y.
    Fingerprinting of natural product by Eastern blotting using monoclonal antibodies.
    Chromatography Research International, 2012: Article ID 130732, 2012.
  6. Sakamoto S, Pongkitwitoon B, Nakahara H, Shibata O, Shoyama Y, Tanaka H, Morimoto S.
    Fluobodies against bioactive natural products and their application in fluorescence-linked immunosorbent assay.
    Antibodies, 1(2):239-258, 2012.
  7. Tanaka H, Paudel M, Takei A, Sakoda J, Juengwatanatrakul T, Sasaki-Tabata K, Putalun W, De-Eknamkul W, Matangkasombut O, Shoyama Y, Morimoto S.
    Immunochemical analysis of the antimalarial drugs artemisinin and artesunate.
    Antibodies, 1(3): 273-283, 2012.
  8. Uto T, Tung N, Morinaga O, Shoyama Y.
    Preparation of knockout extract by immunoaffinity column and its application.
    Antibodies, 1(3):294-307, 2012.
  9. 正山征洋
    モンゴルの資源調査研究
    長崎国際大学論叢,12:149-155, 2012.

2011年

  1. Shoyama Y.
    New strategy for drug discovery using monoclonal antibody.
    Current Drug Discovery Technologies, 8(1):1-2. 2011.
  2. Shang MY, Tian M, Tanaka H, Li XW, Cai SQ, Shoyama Y. Quality control of traditional chinese medicine by monoclonal antibody method.
    Current Drug Discovery Technologies, 8(1):60-65. 2011.
  3. Morinaga O, Shoyama Y.
    Development of new staining technology "eastern blotting" using monoclonal antibody.
    Current Drug Discovery Technologies, 8(1):42-50. 2011.
  4. Uto T, Tuvshintogtokh I, Shoyama Y. Preparation of knockout extract for determination of really active compound using MAb.
    Current Drug Discovery Technologies, 8(1):16-23. 2011.
  5. Shoyama Y.
    Monoclonal antibodies against small molecule natural products and their applications, eastern blotting and knockout extract
    Pharmaceuticals, 4(7), 950-963. 2011.
  6. Shoyama Y.
    Resource of medicinal plants and ecology.
    Journal of Traditional Medicines, 28:20-35, 2011.
  7. Du XM, 正山征洋
    金線連の活性成分
    長崎国際大学論叢,11:119-130, 2011

2010年

  1. 正山征洋
    植物バイオテクノロジーによる薬用植物の育種研究
    長崎国際大学論叢,10:227-237, 2010.

書籍

2017年

  1. 佐竹元吉、正山征洋、和仁皓明(著)/一般財団法人医療経済研究・社会保険福祉協会=編集企画
    “ヒトは何故それを食べるのか: 食経験を考える63のヒント”
    ISBN: 978-4805855881, 中央法規, 2017.11.1
  2. Tanaka H, Wada M, Tung NH, Fujii S, Uto T, Shoyama Y.
    Chapter title: In vitro fertilization activators for future.
    "Research of licorice in the past, present and future - Preparation of various bioactive extracts as alternative medicines"
    ISBN: 978-953-51-5195-1, page 107-117. InTech, 2017.

2016年

  1. 佐竹元吉、黒栁正典、正山征洋、和仁皓明=編著/一般財団法人医療経済研究・社会保険福祉協会=編集企画
    健康・機能性食品の基原植物事典”
    ISBN: 978-4-8058-5408-2, 中央法規, 2016.11.15

2014年

  1. 正山征洋(著)
    ボタニカルアートの薬草手帖
    ISBN: 4816708863, 西日本新聞社,2014.7.28
  2. Tung NH, Soeda S, Saito H, Aritake K, Shoyama Y.
    Chapter 14. Multifunction of saffron and its components in the brain.
    "Food and Brain Health"
    ISBN: 978-1-63117-738-5, page137-150. Nova Science Publishers, 2014.

2013年

  1. 磯田進,鵜池俊子(著),正山征洋(編著)
    身近なアロマセラピー
    ISBN: 9784904962022, 玄海町,2013.3

2012年

  1. 近藤隆一郎,正山征洋,李剛(著)
    薬湯・薬膳・薬酒手帖 - 薬草・薬木による健康の勧め
    ISBN: 9784904962015, 玄海町,2012.3
  2. 正山征洋(著)
    サイコのパワー
    玄海町,2012.8.31
  3. Uto T, Tung NH, Tanaka H, Shoyama Y.
    Chapter 2. Applications of anti-natural compound immunoaffinity purification on quality control.
    "Latest Research into Quality Control"
    ISBN 978-953-51-0868-9, page29-45. InTech, 2012.
  4. Morinaga O, Shoyama Y.
    Chapter 1. Quality control of Rheum and Cassia species by immunological methods using monoclonal antibodies against sennosides.
    "Latest Research into Quality Control"
    ISBN 978-953-51-0868-9, page3-27. InTech, 2012.

2011年

  1. Uto T, Tung NH.
    Chapter 13. Quality control by immunoaffinity concentration using monoclonal antibody.
    "Quality Control of Herbal Medicines and Related Areas"
    ISBN 978-953-307-682-9, page239-254. InTech, 2012.

2010年

  1. 米田該典,安部直樹,嶋内麻佐子,山本源太(著),正山征洋(編著)
    茶花・薬草・薬木手帖 : 野山の散策で見る
    ISBN: 9784904962008, 玄海町,2010.3

特許

  1. メラニン合成促進組成物
    正山征洋,宇都拓洋,太田智絵
    長崎国際大学
    2017年8月1日
    出願番号:特願2017-149066
  2. メラニン合成促進組成物
    正山征洋,宇都拓洋,森永紀,山下明寿,藤井俊輔
    長崎国際大学
    2015年6月2日
    出願番号:特願2015-112380
  3. Novel compounds having a tetracyclic iridoid skeleton and an anti-trypanosomal, anti-Leishmanial and anti-plasmodial agents comprising the same as an active ingredient.
    山岡昇司,太田伸夫,鈴木光子,正山征洋,森永紀,宇都拓洋,Tung NH,Koram KA,Bosompem KM,Nyarko AK,Boakye DA,Ayi I,Appiah-Opong R,Edoh DA,Okine L,Aboagye FA.
    国立大学法人東京医科歯科大学,長崎国際大学,University of Ghana (Noguchi Memorial Institute for Medical Research) ,Centre for Scientific Research Into Plant Medicine (CSRPM)
    2015年1月7日
    国際出願番号:PCT/JP2015/050856

その他

  1. 正山征洋
    冬のボタニカルアート 第1回 ニンニク
    福岡市薬ジャーナル,1:46, 2018.
  2. 正山征洋
    くすりプロムナード 紫河車
    Phil漢方,57:12-13, 2015.
  3. 正山征洋
    くすりプロムナード 当帰
    Phil漢方,55:12-13, 2015.
  4. 正山征洋
    くすりプロムナード チョウトウコウ
    Phil漢方,53:16-17, 2015.
  5. 正山征洋
    くすりプロムナード サフラン
    Phil漢方,52:12-13, 2015.
  6. 秋田徹,黒柳正典,小林公子,佐竹元吉,関田節子,中村玲子,森本隆司,義平邦利,和仁皓明,正山征洋
    天然添加物に関わる基礎的調査研究 ―その1 天然香料―
    長崎国際大学論叢,15:193-202, 2015.
  7. 正山征洋
    最近の生薬事情
    薬用植物研究36(5): 5, 2014
  8. 秋田徹,黒柳正典,小林公子,佐竹元吉,関田節子,中村玲子,森本隆司,義平邦利,和仁皓明,正山征洋
    食品添加物の安全性に関わる調査研究 天然香料
    薬用植物研究,36(2):64-69,2014
  9. 正山征洋
    くすりプロムナード 桔梗(ききょう)
    Phil漢方,51:14-15, 2014.
  10. 正山征洋
    くすりプロムナード 陳皮(ちんぴ)
    Phil漢方,49:12-13, 2014.
  11. 正山征洋
    くすりプロムナード 朮(じゅつ)
    Phil漢方,47:12-13, 2014.
  12. 正山征洋
    くすりプロムナード ジオウ
    Phil漢方,46:12-13, 2014.
  13. 正山征洋
    くすりプロムナード オタネニンジン
    Phil漢方,45:14-15, 2013.
  14. 正山征洋
    くすりプロムナード 半夏
    Phil漢方,43:12-13, 2013.
  15. 正山征洋
    くすりプロムナード 柴胡
    Phil漢方,42:12-13, 2013.
  16. 正山征洋
    くすりプロムナード 甘草
    Phil漢方,41:12-13, 2013.
  17. 宇都拓洋
    フラボノイドでがん予防 ~ルテオリンの標的分子解明~
    ファルマシア,9(8):797, 2013.
  18. 正山征洋
    随想 漢方薬の危機 
    日中医学,24(6):33,2013
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