長崎国際大学 薬学部 薬品資源学研究室

MENU

研究業績(宇都 拓洋)

原著論文

2019年

  1. Uto T, Ohta T, Yamashita A, Fujii S, Shoyama Y.
    Liquiritin and liquiritigenin induce melanogenesis via enhancement of p38 and PKA signaling pathways.
    Medicines, 2019. In press.
  2. Okubo S, Komori H, Kuwahara A, Ohta T, Shoyama Y, Uto T.
    Screening of crude drugs used in Japanese Kampo formulas for autophagy-mediated cell survival of the human hepatocellular carcinoma cell line.
    Medicines, 2019. In press.
  3. Fujimoto K, Ohta T, Yamaguchi H, Tung NH, Fujii G, Mutoh M, Uto T, Shoyama Y.
    Suppression of polyps formation by saffron extract in Adenomatous polyposis coliMin/+ Mice.
    Pharmacognosy Research, 11(1):98-101. 2019.
  4. Ohta T, Tilkanont T, Ayertey F, Nakagawa M, Tung NH, Bolah P, Blagogee H, Appiah AA, Ocloo A, Ohashi M, Tanoue K, Yamaguchi Y, Ohta N, Yamaoka S, Iwanaga S, Uto T, Shoyama Y.
    Establishment of a quantitative and qualitative analysis and isolation method for tetracyclic iridoids from Morinda lucida Bentham leaves.
    Journal of Pharmaceutical and Biomedical Analysis, 164:475-480. 2019.

2018年

  1. Azerigyik FA, Amoa-Bosompem M, Tetteh T, Ayertey F, Antwi AN, Owusu KB, Dadzie KK, Djameh GI, Tetteh-Tsifoanya M, Iwanaga S, Appiah AA, Ohta T, Uto T, Shoyama Y, Ohta N, Gwira TM, Ohashi M.
    In vitro mechanistic assays of tetracyclic iridoid compounds isolated from Morinda lucida Benth in Leishmania species.
    European Journal of Medical Plants, 25(4). 1-14. 2018.
  2. Ohashi M, Amoa-Bosompem M, Kwofie KD, Agyapong J, Adegle R, Sakyiamah MM, Ayertey F, Owusu KB, Tuffour I, Atchoglo P, Tung NH, Uto T, Aboagye F, Appiah AA, Appiah-Opong R, Nyarko AK, Anyan WK, Ayi I, Boakye DA, Koram KA, Edoh D, Yamaoka S, Shoyama Y,Ohta N.
    In vitro anti-protozoan activity and mechanisms of action of selected Ghanaian medicinal plants against Trypanosoma, Leishmania and Plasmodium parasites.
    Phytotherapy Research, 32(8):1617-1630. 2018.
  3. Uto T, Tung NH, Ohta T, Juengsanguanpornsuk W, Hung LQ, Hai NT, Long DD, Thuong PT, Okubo S, Hirata S, Shoyama Y. Antiproliferative activity and apoptosis induction by trijuganone C isolated from the root of Salvia miltiorrhiza Bunge (Danshen).
    Phytotherapy Research, 32(4):657-666. 2018.
  4. Fujii S, Uto T, Nomura S, Shoyama Y.
    Preparation of anti-glycyrrhetinic acid monoclonal antibody for application in an indirect competitive enzyme-linked immunosorbent assay.
    Analytical Letters, 51(8): 1147-1162. 2018.

2017年

  1. Antwi AN, Owusu KBA, Amoa-Bosompem M, Williams NB, Ayertey F, Akyeh L, Agyapong J, Tetteh T, Djameh GI, Botchie S, Azerigyik F, Ablordey A, Tung NH, Uto T, Appiah AA, Iwanaga S, Shoyama Y, Ohta N, Egyir B, Ohashi M.
    Anti-microbial activities of selected Ghanaian medicinal plants and four structurally similar anti-protozoan compounds against susceptible and multi-drug resistant bacteria.
    European Journal of Medical Plants, 20(2):1-14. 2017.
  2. Okubo S, Uto T, Goto A, Tanaka H, Nishioku T, Yamada K, Shoyama Y.
    Berberine induces apoptotic cell death via activation of caspase-3 and -8 in HL-60 human leukemia cells: Nuclear localization and structure-activity relationships.
    The American Journal of Chinese Medicine, 45(7):1497-1511. 2017.
  3. Tung NH, Nakajima K, Uto T, Hai NT, Long DD, Ohta T, Oiso S, Kariyazono H, Shoyama Y.
    Bioactive triterpenes from the root of Salvia miltiorrhiza Bunge.
    Phytotherapy Research, 31(9):1457-1460. 2017.
  4. Tung NH, Uto T, Hai NT, Li G, Shoyama Y.
    Quassinoids from the root of Eurycoma longifolia and their antiproliferative activity on human cancer cell lines.
    Pharmacognosy Magazine, 13(51):459-462. 2017.
  5. Fujii S, Morinaga O, Uto T, Nomura S, Shoyama Y.
    Simultaneous determination of glycyrrhizin and liquiritin in licorice roots and Kampo medicines by combination enzyme-linked immunosorbent assay using anti-glycyrrhizin and anti-liquiritin monoclonal antibodies.
    Journal of Immunoassay and Immunochemistry, 38(3):285-298. 2017.

2016年

  1. Nakajima K, Oiso S, Uto T, Morinaga O, Shoyama Y, Kariyazono H.
    Triterpenes suppress octanoylated ghrelin production in ghrelin-expressing human gastric carcinoma cells.
    Biomedical Research, 37(6):343-349. 2016.
  2. Appiah-Opong R, Tuffour I, Annor GK, Blankson-Darku AD, Cramer P, Kissi-Twum AA, Uto T, Ocloo A.
    Antiproliferative, antioxidant activities and apoptosis induction by Morinda lucida and Taraxacum officinale in human HL-60 leukemia cells.
    Journal of Global Biosciences, 5(7):4281-4291. 2016.
  3. Amoa-Bosompem M, Ohashi M, Mosore MT, Agyapong J, Tung NH, Kwofie KD, Ayertey F, Owusu KB, Tuffour I, Atchoglo P, Djameh GI, Azerigyik FA, Botchie SK, Anyan WK, Appiah-Opong R, Uto T, Morinaga O, Appiah AA, Ayi I, Shoyama Y, Boakye DA, Ohta N.
    In vitro anti-Leishmania activity of tetracyclic iridoids from Morinda lucida, benth.
    Tropical Medicine and Health, 44:25. doi: 10.1186/s41182-016-0026-5. 2016.
  4. Tung NH, Uto T, Isoda S, Shoyama Y.
    Investigation of ginsenoside Rb1 from Acanthopanax koreanum by Eastern blotting and ELISA analyses.
    Pharmaceutical Analytical Chemistry, 2:116. doi:10.4172/2471-2698.1000116. 2016.
  5. Uto T, Tung NH, Thongjankaew P, Lhieochaiphant S, Shoyama Y.
    Kayeassamin A isolated from the flower of Mammea siamensis triggers apoptosis by activating caspase-3/-8 in HL-60 human leukemia cells.
    Pharmacognosy Research, 8(4):244-248. 2016.
  6. Kwofie KD, Tung NH, Suzuki-Ohashi M, Amoa-Bosompem M, Adegle R, Sakyiamah MM, Ayertey F, Owusu KB, Tuffour I, Atchoglo P, Frempong KK, Anyan WK, Uto T, Morinaga O, Yamashita T, Aboagye F, Appiah AA, Appiah-Opong R, Nyarko AK, Yamaguchi Y, Edoh D, Koram KA, Yamaoka S, Boakye DA, Ohta N, Shoyama Y, Ayi I.
    Antitrypanosomal activities and mechanisms of action of novel tetracyclic iridoids from Morinda lucida Benth.
    Antimicrobial Agents and Chemotherapy, 60(6):3283-3290. 2016.
  7. Fujii S, Morinaga O, Uto T, Nomura S, Shoyama Y.
    Development of double eastern blotting for major licorice components, glycyrrhizin and liquiritin for chemical quality control of licorice using anti-glycyrrhizin and anti-liquiritin monoclonal antibodies.
    Journal of Agricultural and Food Chemistry, 64(5):1087-1089. 2016.
  8. Appiah-Opong R, Asante IK, Safo DO, Tuffour I, Ofori-Attah E, Uto T, Nyarko AK.
    Antioxidant and cytotoxic effects of Albizia zygia (DC) J.F. Macbr , a Ghanaian medicinal plants towards leukemia, prostate and breast cancer cell lines.
    International Journal of Pharmacy and Pharmaceutical Sciences, 8(5): 392-396. 2016.

2015年

  1. Karasawa S, Yoza K, Tung NH, Uto T, Morinaga O, Suzuki M, Kwofie K.D., Amoa-Bosompem M, Boakye DA, Ayi I, Adegle R, Sakyiamah M, Ayertey F, Aboagye F, Appiah AA, Owusu KB, Tuffour I, Atchoglo P, Frempong KK, Anyan WK, Appiah-Opong R, Nyarko AK, Yamashita T, Yamaguchi Y, Edoh D, Koram K, Yamaoka S, Ohta N, Shoyama Y.
    Determination of the absolute configuration of the novel anti-trypanosomal iridoid molucidin isolated from Morinda lucida by X-ray analysis.
    Tetrahedron Letters, 56(52):7158-7160. 2015.
  2. Uto T, Tung NH, Taniyama R, Miyanowaki T, Morinaga O, Shoyama Y.
    Anti-inflammatory activity of constituents isolated from aerial part of Angelica acutiloba Kitagawa.
    Phytotherapy Research, 29(12): 1956-1963. 2015.
  3. Uto T, Tung NH, Appiah-Opong R, Aning A, Morinaga O, Edoh D, Nyarko AK, Shoyama Y.
    Antiproliferative and pro-apoptotic activity of diarylheptanoids isolated from the bark of Alnus japonica in human leukemia cell lines.
    American Journal of Chinese Medicine, 43(4):757-767. 2015.
  4. Tung NH, Uto T, Morinaga O, Shoyama Y.
    Chemical constituents from the aerial parts of Bupleurum falcatum L. and biological evidences.
    Natural Product Sciences, 21(2), 71-75. 2015.
  5. Suzuki M, Tung NH, Kwofie KD, Adegle R, Amoa-Bosompem M, Sakyiamah M, Ayertey F, Owusu KB, Tuffour I, Atchoglo P, Frempong KK, Anyan WK, Uto T, Morinaga O, Yamashita T, Aboagye F, Appiah AA, Appiah-Opong R, Nyarko AK, Yamaoka S, Yamaguchi Y, Edoh D, Koram K, Ohta N, Boakye DA, Ayi I, Shoyama Y.
    New anti-trypanosomal active tetracyclic iridoid isolated from Morinda lucida Benth.
    Bioorganic & Medicinal Chemistry Letters, 25(15):3030-3033. 2015
  6. Hori T, Barnor J, Huu TN, Morinaga O, Hamano A, Ndzinu J, Frimpong A, Minta-Asare K, Amoa-Bosompem M, Brandful J, Odoom J, Bonney J, Tuffour I, Owusu BA, Ofosuhene M, Atchoglo P, Sakyiamah M, Adegle R, Appiah-Opong R, Ampofo W, Koram K, Nyarko A, Okine L, Edoh D, Appiah A, Uto T, Yoshinaka Y, Uota S, Shoyama Y, Yamaoka S.
    Procyanidin trimer C1 derived from Theobroma cacao reactivates latent human immunodeficiency virus type 1 provirus.
    Biochemical and Biophysical Research Communications, 459(2):288-293. 2015.
  7. Oiso S, Morinaga O, Goroku T, Uto T, Shoyama Y, Kariyazono H.
    Generation of an anti-dabigatran monoclonal antibody and its use in a highly sensitive and specific enzyme-linked immunosorbent assay for serum dabigatran.
    Therapeutic Drug Monitoring, 37(5):594-599. 2015.
  8. Sakamoto S, Uto T, Shoyama Y.
    Effect of glycyrrhetinic acid on lipid raft model at the air/water interface.
    Biochimica et Biophysica Acta (BBA), 1848(2):434-443. 2015.
  9. Larbie C, Appiah-Opong R, Acheampong F, Tuffour I, Uto T, Torkornoo D, Marfo E, Ankamah-Mensah D,Opoku-Mensah E, Abotsi P.
    Anti-proliferative effect of Amaranthus viridis Linn. On human leukemic cell lines-a preliminary study.
    International Journal of Biological & Pharmaceutical Research, 6(3):236-243, 2015.
  10. Hagimori M, Temma T, Mizuyama N, Uto T, Yamaguchi Y, Tominaga Y, Mukai T, Saji H.
    A high-affinity fluorescent Zn2+ sensor improved by the suppression of pyridine-pyridone tautomerism and its application in living cells.
    Sensors and Actuators B: Chemical, 213(2015): 45–52, 2015.

2014年

  1. Tung NH, Suzuki M, Uto T, Morinaga O, Kwofie KD, Ammah N, Koram KA, Aboagye F, Edoh D, Yamashita T, Yamaguchi Y, Setsu T, Yamaoka S, Ohta N, Shoyama Y.
    Anti-trypanosomal activity of diarylheptanoids isolated from the bark of Alnus japonica.
    American Journal of Chinese Medicine, 2014;42(5):1245-1260. 2014.
  2. Fujii S, Tuvshintogtokh I, Mandakh B, Munkhjargal B, Uto T, Morinaga O, Shoyama Y.
    Screening of Glycyrrhiza uralensis Fisch. ex DC. containing high concentrations of glycyrrhizin by Eastern blotting and enzyme-linked immunosorbent assay using anti-glycyrrhizin monoclonal antibody for selective breeding of licorice.
    Journal of Natural Medicines, 68(4):717-722. 2014.
  3. Fujii S, Morinaga O, Uto T, Nomura S, Shoyama Y.
    Development of a monoclonal antibody-based immunochemical assay for liquiritin and its application to the quality control of licorice products.
    Journal of Agricultural and Food Chemistry, 62(15):3377-3383. 2014.

2013年

  1. Li XW, Morinaga O, Tian M, Uto T, Yu J, Shang MY, Wang X, Cai SQ, Shoyama Y.
    Development of an Eastern blotting technique for the visual detection of aristolochic acids in Aristolochia and Asarum species by using a monoclonal antibody against aristolochic acids I and II.
    Phytochemical Analysis, 24(6):645-653. 2013.
  2. Uto T, Sakamoto A, Tung NH, Fujiki T, Kishihara K, Oiso S, Kariyazono H, Morinaga O, Shoyama Y.
    Anti-proliferative activities and apoptosis induction by triterpenes derived from Eriobotrya japonica in human leukemia cell lines.
    International Journal of Molecular Sciences, 14(2): Article ID 4106-20. 2013.
  3. Sakamoto S, Nakahara H, Uto T, Shoyama Y, Shibata O.
    Investigation of interfacial behavior of glycyrrhizin with a lipid raft model via a Langmuir monolayer study.
    Biochimica et Biophysica Acta (BBA), 1828(4):1271-1283. 2013.
  4. Morinaga O, Lu Z, Lin L, Uto T, Sangmalee S, Putalun W, Tanaka H, Shoyama Y.
    Detection of paeoniflorin and albiflorin by immunostaining technique using anti-paeoniflorin monoclonal antibody.
    Phytochemical Analysis, 24(2):124-128. 2013.
  5. Uto T, Tung NH, Morinaga O, Shoyama Y.
    Interaction analysis of glycyrrhizin on licorice extract-induced apoptosis of human leukemia cells by knockout extract.
    Natural Products Chemistry & Research, 1(105): Article ID 1000105. 2013.
  6. Kyeremeh K, Obed A, Kojo BS, Tuffour I, Uto T, Appiah-Opong R.
    Bioactivity data for eunicellin-based diterpenes isolated from Acalycigorgia sp.
    International Journal of Applied Chemistry, 9(2):141-150, 2013.
  7. Hagimori M, Uto T, Mizuyama N, Temma T, Yamaguchi Y, Tominaga Y, Saji H.
    Fluorescence ON/OFF switching Zn2+ sensor based on pyridine–pyridone scaffold.
    Sensors & Actuators B: Chemical, 181:823-828. 2013.
  8. Tung NH, Uto T, Sakamoto A, Hayashida Y, Hidaka Y, Morinaga O, Lhieochaiphant S, Shoyama Y.
    Antiproliferative and apoptotic effects of compounds from the flower of Mammea siamensis (Miq.) T. Anders. on human cancer cell lines.
    Bioorganic & Medicinal Chemistry Letters, 23(1):158-162. 2013.

2012年

  1. Uto T, Morinaga O, Tanaka H, Shoyama Y.
    Analysis of the synergistic effect of glycyrrhizin and other constituents in licorice extract on lipopolysaccharide-induced nitric oxide production using knock-out extract.
    Biochemical and Biophysical Research Communications, 417(1):473-478. 2012.
  2. Uto T, Qin GW, Morinaga O, Shoyama Y.
    17-Hydroxy-jolkinolide B, a diterpenoid from Euphorbia fischeriana, inhibits inflammatory mediators but activates heme oxygenase-1 expression in lipopolysaccharide-stimulated murine macrophages.
    International Immunopharmacology, 12(1):101-109. 2012.
  3. Morinaga O, Mukae R, Uto T, Pariyawongsakul Y, Putalun W, Tanaka H, Shoyama Y.
    Development of Eastern blotting technique for analysis of baicalin using anti-baicalin monoclonal antibody.
    Antibodies, 1(3): 284-293, 2012.

2011年

  1. Yokota S, Onohara Y, Uto T, Tanaka H, Morinaga O, Shoyama Y.
    Localization of ginsenoside-Rb1 in Panax ginseng revealed by immunofluorescence and immunoelectron microscopic techniques.
    Journal of Medicinal Plants Research, 5(14): 3176-3187, 2011.
  2. Chen J, Qin S, Xiao J, Tanigawa S, Uto T, Hashimoto F, Fujii M, Hou DX.
    A genome-wide microarray highlights the antiinflammatory genes targeted by oolong tea theasinensin A in macrophages.
    Nutrition and Cancer, 63(7):1064-1073. 2011.

2010年

  1. Uto T, Suangkaew N, Morinaga O, Kariyazono H, Oiso S, Shoyama Y.
    Eriobotryae folium extract suppresses LPS-induced iNOS and COX-2 expression by inhibition of NF-B and MAPK activation in murine macrophages.
    American Journal of Chinese Medicine, 38(5):985-994. 2010.
  2. Morinaga O, Uto T, Yuan CS, Tanaka H, Shoyama Y.
    Evaluation of a new eastern blotting technique for the analysis of ginsenoside Re in American ginseng berry pulp extracts.
    Fitoterapia, 81(4):284-288. 2010.
  3. Khan M, Singh J, Gilg AG, Uto T, Singh I.
    Very long-chain fatty acid accumulation causes lipotoxic response via 5-lipoxygenase in cerebral adrenoleukodystrophy.
    Journal of Lipid Research, 51(7):1685-1695. 2010.
  4. Chen J, Uto T, Tanigawa S, Yamada-Kato T, Fujii M, Hou DX.
    Microarray-based determination of anti-inflammatory genes targeted by 6-(methylsulfinyl)hexyl isothiocyanate in macrophages.
    Experimental and Therapeutic Medicine, 1(1):33-40. 2010.

2009年

  1. Morinaga O, Uto T, Sakamoto S, Putalun W, Lhieochaiphant S, Tanaka H, Shoyama Y.
    Development of eastern blotting technique for sennoside A and sennoside B using anti-sennoside A and anti-sennoside B monoclonal antibodies.
    Phytochemical Analysis, 20(2):154-158. 2009.
  2. Morinaga O, Uto T, Sakamoto S, Tanaka H, Shoyama Y.
    Enzyme-linked immunosorbent assay for total sennosides using anti-sennside A and anti-sennoside
    B monoclonal antibodies.
    Fitoterapia, 80(1):28-31. 2009.

2008年

  1. Uto T, Contreras MA, Gilg AG, Singh I.
    Oxidative imbalance in nonstimulated X-adrenoleukodystrophy-derived lymphoblasts.
    Developmental Neuroscience, 30(6):410-418. 2008.
  2. Chen J, Uto T, Tanigawa S, Kumamoto T, Fujii M, Hou DX.
    Expression profiling of genes targeted by bilberry (Vaccinium myrtillus) in macrophages through DNA microarray.
    Nutrition and Cancer, 60(Suppl 1):43-50.2008.
  3. Contreras MA, Haq E, Uto T, Singh I, Singh AK.
    Psychosine-induced alterations in peroxisomes of twitcher mouse liver.
    Archives of Biochemistry and Biophysics, 477(2):211-218. 2008.
  4. Du M., Irino N., Uto T., Morinaga O., Shoyama Y.
    Micropropagation of Anoectochilus formosanus Hayata in vitro and pharmacological and chemical investigations.
    Current Topics in Phytochemistry, 9:79-87, 2008.

2007年

  1. Hou DX, Luo D, Tanigawa S, Hashimoto F, Uto T, Masuzaki S, Fujii M, Sakata Y.
    Prodelphinidin B-4 3'-O-gallate, a tea polyphenol, is involved in the inhibition of COX-2 and iNOS via the downregulation of TAK1-NF-κB pathway.
    Biochemical Pharmacology, 74(5):742-51. 2007.
  2. Hou DX, Masuzaki S, Hashimoto F, Uto T, Tanigawa S, Fujii M, Sakata Y.
    Green tea proanthocyanidins inhibit cyclooxygenase-2 expression in LPS-activated mouse macrophages: molecular mechanisms and structure-activity relationship.
    Archives of Biochemistry and Biophysics, 460(1):67-74. 2007.
  3. Uto T, Fujii M, Hou DX.
    Effects of 6-(methylsulfinyl)hexyl isothiocyanate on cyclooxygenase-2 expression induced by lipopolysaccharide, interferon-gamma and 12-O-tetradecanoylphorbol-13-acetate.
    Oncology Reports, 17(1):233-238. 2007.

2006年

2005年

  1. Uto T, Fujii M, Hou DX.
    Inhibition of lipopolysaccharide-induced cyclooxygenase-2 transcription by 6-(methylsulfinyl) hexyl isothiocyanate, a chemopreventive compound from Wasabia japonica (Miq.) Matsumura, in mouse macrophages.
    Biochemical Pharmacology, 70(12):1772-1784. 2005.
  2. Uto T, Fujii M, Hou DX.
    6-(Methylsulfinyl)hexyl isothiocyanate suppresses inducible nitric oxide synthase expression through the inhibition of Janus kinase 2-mediated JNK pathway in lipopolysaccharide-activated murine macrophages.
    Biochemical Pharmacology, 70(8):1211-1221. 2005.
  3. Hou DX, Yanagita T, Uto T, Masuzaki S, Fujii M.
    Anthocyanidins inhibit cyclooxygenase-2 expression in LPS-evoked macrophages: structure-activity relationship and molecular mechanisms involved.
    Biochemical Pharmacology, 70(3):417-425. 2005.

2004年

  1. Hou DX, Uto T, Tong X, Takeshita T, Tanigawa S, Imamura I, Ose T, Fujii M.
    Involvement of reactive oxygen species-independent mitochondrial pathway in gossypol-induced apoptosis.
    Archives of Biochemistry and Biophysics, 428(2):179-187. 2004.

2003年

  1. Hou DX, Ose T, Lin S, Harazoro K, Imamura I, Kubo M, Uto T, Terahara N, Yoshimoto M, Fujii M.
    Anthocyanidins induce apoptosis in human promyelocytic leukemia cells: structure-activity relationship and mechanisms involved.
    International Journal of Oncology, 23(3):705-712. 2003.

総説

  1. Dai HF, Ohta T, Uto T, Shoyama Y.
    New development of artificial agarwood in Hainan in China.
    薬用植物研究, 40(1):1-10. 2018.
  2. 藤井 俊輔, 宇都 拓洋, 正山 征洋
    天然化合物特異的モノクローナル抗体を用いた薬用植物の品質評価法
    アグリバイオ, 1(7):62-65. 2017.
  3. 藤井 俊輔, 宇都 拓洋, 正山 征洋
    甘草含有成分に対するモノクローナル抗体を用いた甘草の品質評価法の開発
    アグリバイオ, 1(4):72-75. 2017.
  4. Uto T, Tung NH, Nakajima K, Ohta T, Oiso S, Kariyazono H, Shoyama Y.
    Bioactivities of Eriobotrya japonica (Thunb.) Lindl. leaf and its triterpenes.
    Journal of Pharmacognosy & Natural Products, 3:134. doi: 10.4172/2472-0992.1000134. 2017.
  5. Fujii S, Tung NH, Uto T, Tanaka H, Li XW, Cai SQ, Putalum W, Shoyama Y.
    Quality control of natural products by fingerprinting of eastern blotting.
    Pharmaceutica Analytica Acta, 7:494. doi: 10.4172/2153-2435.1000494. 2016.
  6. Tung NH, Wang CZ, Du GJ, Yuan CS, Uto T, Shoyama Y.
    Chemopreventive activity of naphthoquinones from Alkanna tinctoria (L.) Tausch in human colorectal cancer cells.
    Journal of Gastroenterology and Hepatology Research, 5(4):2115-2121. 2016.
  7. Tung NH, Tanaka H, Tsujimura A, Miyagawa Y, Wada M, Fujii S, Uto T, Shoyama Y.
    In vitro fertilization with mouse sperm activated by components of licorice root extract.
    Natural Products Chemistry & Research, 4(3), doi:10.4172/2329-6836.1000217. 2016.
  8. 宇都拓洋, Tung NH, 正山征洋
    生薬未利用部位の開発研究 柴胡・当帰
    薬用植物研究,37(2):38-48. 2015.
  9. Putalun W., Tanaka H., Wakana A., Uto T., Shoyama Y.
    Missile-type molecular breeding of medicinal plant using compact monoclonal antibody gene.
    EC Agriculture, 2(3), 358-365. 2015.
  10. 宇都拓洋
    天然物に対する特異的モノクローナル抗体を用いた生薬成分の機能解析
    薬学雑誌,134(10):1061-1067. 2014.
  11. Huu Tung N, Uto T, Morinaga O, Kim YH, Shoyama Y.
    Pharmacological effects of ginseng on liver functions and diseases: a minireview.
    Evidence-Based Complementary and Alternative Medicine, 2012: Article ID 173297. 2012.
  12. Uto T, Hou DX, Morinaga O, Shoyama Y.
    Molecular mechanisms underlying anti-inflammatory actions of 6-(methylsulfinyl)hexyl isothiocyanate derived from wasabi (Wasabia japonica).
    Advances in Pharmacological Sciences, 2012: Article ID 614046. 2012.
  13. Tanaka H, Morinaga O, Uto T, Fuji S, Aboagye FA, Tung NH, Li XW, Putalun W, Shoyama Y.
    Application of monoclonal antibodies against bioactive natural products: Eastern blotting and preparation of knockout extract.
    International Journal of Analytical Chemistry, 2012: Article ID 260425. 2012.
  14. Kwon ST, Uto T, Morinaga O, Tung NH, Tanaka H, Yuan CS, Shoyama Y.
    A new strategy of immunostaining for identification of ginsenosides.
    International Journal of Biomedical and Pharmaceutical Sciences, 6(Special issue 1): 101-105, 2012.
  15. Uto T, Tung N, Morinaga O, Shoyama Y.
    Preparation of knockout extract by immunoaffinity column and its application.
    Antibodies, 1(3):294-307, 2012.
  16. Uto T, Tuvshintogtokh I, Shoyama Y.
    Preparation of knockout extract for determination of really active compound using MAb.
    Current Drug Discovery Technologies, 8(1):16-23. 2011.
  17. 森永紀,宇都拓洋,正山征洋
    センノサイドA,Bの免疫化学的測定法の開発について
    長崎国際大学論叢,9:75-84, 2009.
  18. 宇都拓洋
    6-(Methylsulfinyl) hexyl Isothiocyanateによる抗炎症及び抗癌作用の分子機構
    長崎国際大学論叢,8:249-264, 2008.
  19. Morinaga O, Uto T, Sakamoto S, Tanaka H, Shoyama Y.
    Visual detection and quantitative analysis of bioactive compound contained in traditional Chinese medicines based on new eastern blotting.
    Trends in Chromatography, 3:43-51, 2007.

書籍

  1. Tanaka H, Wada M, Tung NH, Fujii S, Uto T, Shoyama Y.
    Chapter title: In vitro fertilization activators for future.
    "Research of licorice in the past, present and future - Preparation of various bioactive extracts as alternative medicines"
    ISBN: 978-953-51-5195-1, page 107-117. InTech, 2017.
  2. Uto T, Tung NH, Tanaka H, Shoyama Y.
    Chapter 2. Applications of anti-natural compound immunoaffinity purification on quality control.
    "Latest Research into Quality Control"
    ISBN 978-953-51-0868-9, page29-45. InTech, 2012.
  3. Uto T, Tung NH.
    Chapter 13. Quality control by immunoaffinity concentration using monoclonal antibody.
    "Quality Control of Herbal Medicines and Related Areas"
    ISBN 978-953-307-682-9, page239-254. InTech, 2012.

その他の出版物

  1. 宇都拓洋
    フラボノイドでがん予防 ~ルテオリンの標的分子解明~
    ファルマシア,9(8):797, 2013.
  2. 正山征洋,宇都拓洋
    漢方薬・生薬の活性評価―有効成分のノックアウトエキスと薬理解析
    臨床検査,53:943-946,2009.
  3. 正山征洋,宇都拓洋
    連載・目で見る漢方薬・生薬1、甘草(カンゾウ)
    医薬ジャーナル,45(1):7-13,2009.

特許

  1. メラニン合成促進組成物
    正山征洋,宇都拓洋,太田智絵
    長崎国際大学
    2017年8月1日
    出願番号:特願2017-149066
  2. メラニン合成促進組成物
    正山征洋,宇都拓洋,森永紀,山下明寿,藤井俊輔
    長崎国際大学
    2015年6月2日
    出願番号:特願2015-112380
  3. Novel compounds having a tetracyclic iridoid skeleton and an anti-trypanosomal, anti-Leishmanial and anti-plasmodial agents comprising the same as an active ingredient.
    山岡昇司,太田伸夫,鈴木光子,正山征洋,森永紀,宇都拓洋,Tung NH,Koram KA,Bosompem KM,Nyarko AK,Boakye DA,Ayi I,Appiah-Opong R,Edoh DA,Okine L,Aboagye FA.
    国立大学法人東京医科歯科大学,長崎国際大学,University of Ghana (Noguchi Memorial Institute for Medical Research) ,Centre for Scientific Research Into Plant Medicine (CSRPM)
    2015年1月7日
    国際出願番号:PCT/JP2015/050856

取得学位

鹿児島大学大学院 連合農学研究科 生物資源利用科学専攻
博士(農学),連研第524号,2006年3月
博士論文題目:Molecular Mechanisms of Anti-inflammatory and Anti-cancer Effects of 6-(Methylsulfinyl)hexyl Isothiocyanate: Cyclooxygenase-2 and Inducible Nitric Oxide Synthase as Target Molecules.

学外の表彰

  1. 2017年9月:日本生薬学会 学術奨励賞
  2. 2013年12月:日本薬学会九州支部 学術奨励賞
  3. 2013年11月:第5回食品薬学シンポジウム 優秀発表賞
  4. 2012年11月:日本薬学会 生薬天然物部会 奨励研究賞

学内の表彰

  1. 2019年5月:ベストティーチャー賞 ベストプラクティス部門(地域貢献活動等、共同受賞)
  2. 2017年5月:ベストティーチャー賞 ベストプラクティス部門(研究活動等)

研究資金の採択状況

  1. 2019年5月~2020年2月:学長裁量経費 大学間連携研究 (代表)
  2. 2019年度~2022年度:科学研究費 基盤研究C(代表)
  3. 2016年度~2018年度:科学研究費 若手研究B(代表)
  4. 2016年4月~2017年3月:東洋食品研究所 研究助成(代表)
  5. 2015年度~2019年度:感染症研究国際展開戦略プログラム 日本医療研究開発機構(分担)
  6. 2013年11月~2015年10月:コスメトロジー研究振興財団 研究助成(代表)
  7. 2013年度~2015年度:科学研究費 若手研究B(代表)
  8. 2010年度~2014年度:地球規模課題対応国際科学技術協力事業(SATREPS) JICA-JST
  9. 2010年度4月~2011年3月:日本私立学校振興・共済事業団 学術研究振興資金(分担)
  10. 2008年11月~2010年10月:武田科学振興財団 薬学系研究奨励金(代表)
  11. 2008年4月~2009年3月:科学技術振興機構 シーズ発掘試験A(発掘型)(代表)
  12. 2008年4月~2009年3月:日本食品化学研究振興財団 研究助成 課題研究(代表)
  13. 2008年4月~2009年3月:アサヒビール学術振興財団 第23回 研究助成(代表)
  14. 2008年4月~2009年3月:日本科学協会 笹川科学研究助成(代表)
  15. 2008年4月~2009年3月:日中医学交流事業共同研究(分担)
  16. 2007年度~2008年度:科学研究費 萌芽(分担)

学会活動

«所属学会名»

日本薬学会、日本生薬学会、日本フードファクター学会、日本分子生物学会

«学会運営、学会誌編集への参加状況»

  1. 2007年10月:Asian Symposium for Pharmaceutical Science(福岡)、実行委員
  2. 2014年11月:日本フードファクター学会年会(鹿児島)、実行委員
  3. 2014年11月~:Evidence-Based Complementary and Alternative Medicine, Editorial Board Member
  4. 2016年4月~2018年3月:日本薬学会ファルマシアトピックス小委員
  5. 2016年4月~現在:日本生薬学会代議員
  6. 2016年12月~現在:日本フードファクター学会(JSoFF)評議員
  7. 2018年4月~現在:日本生薬学会関西支部委員

«学術論文等の審査»

外国語雑誌査読論文数日本語雑誌査読論文数合計
2019年55
2018年99
2017年1616
2016年17118
2015年1111
2014年99
2013年66
2012年55
2011年66
2010年66

その他

«大学での集中講義・セミナー等»

  1. 「食品機能化学特別講義(集中講義)」
    鹿児島大学農学部(3,4年生対象),2015年8月
  2. 「生物資源化学セミナー」
    鹿児島大学農学部,2014年10月3日
  3. 「第1回薬学研究発表会」
    長崎国際大学薬学部,2010年9月9日
  4. 「人材養成学生支援セミナーI」
    鹿児島大学大学院連合農学研究科,2010年8月19-20日
  5. 「アジア研究教育拠点事業(日本学術振興会)によるセミナー」
    北京大学大学院薬学研究科,2009年3月25日

«招待講演»

  1. Food for Health International Conference 2017 (FOHIC2017) (中国、長沙市)
    講演タイトル「(+)-Magnolin isolated form Magnolia flower activates melanogenesis; Involvement of p38 and PKA signaling pathways」

«市民向け講演会等»

  1. 佐世保まちなか大学「自然からのくすり発見アドベンチャー」
    佐世保市,2014年10月18日

«高校生向けの講演や出張講義»

  1. 猶興館高等学校(長崎県平戸市),出張講義,2018年12月17日
  2. 夢ナビライブ(福岡マリンメッセ),講義ライブ,2018年10月20日
  3. 聖和女子学院高等学校(佐世保市),出張講義,2018年7月13日

«新聞報道等»

  1. 生薬成分の相乗効果解析~長崎国際大・宇都助教ら「ノックアウトエキス」使い成功~
    長崎新聞,2013年1月3日
Page Top